Comparison of Cerebellar Grey Matter Alterations in Bipolar and Cerebellar Patients: Evidence from Voxel-Based Analysis

The aim of this study was to compare the patterns cerebellar alterations associated with bipolar disease those induced by presence neurodegenerative pathologies clarify potential contribution affective disturbance. Twenty-nine patients affected disorder, 32 subjects pathologies, and 37 age-matched healthy underwent a 3T MRI protocol. A voxel-based morphometry analysis used show similarities differences in grey matter (GM) loss between groups. We found pattern GM both groups that involved anterior posterior regions (p = 0.05). direct comparison demonstrated significant difference bilateral motor regions, such as lobules I?IV, V, VI, VIIIa, VIIIb, IX, VIIb vermis while overlapping evident right lobule crus I II. Our findings showed, for first time, common different alteration specific patients, which allowed us hypothesize role cognitive mood dysregulation symptoms characterize disorder.